Anti-NSUN4 Antibody Picoband® 31.0550 Vervoeging

NSUN4 belongsto a family of RNA 5-methylcytosine (m5C) methyltransferases (MTases) .MTERF4 recruits NSUN4 to the large ribosomal subunit in a process crucial for mitochondrial ribosome biogenesis. NSUN4 is a dual function protein, which on the one hand is needed for 12S rRNA methylation, and on the other hand interacts withMTERF4 to facilitate mitoribosomal assembly. The calculatedMWof NSUN4 is 43 kDa, 29786-1-AP can detect the band around 40 kDa.

NSUN4

387338

Q96CB9

Human

E.coli-derived human NSUN4 recombinant protein (Position: M1-K379) . Human NSUN4 shares 86.3% amino acid (aa) sequence identity with mouse NSUN4.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Camara, Y., Asin-Cayuela, J., Park, C. B., Metodiev, M. D., Shi, Y., Ruzzenente, B., Kukat, C., Habermann, B., Wibom, R., Hultenby, K., Franz, T., Erdjument-Bromage, H., Tempst, P., Hallberg, B. M., Gustafsson, C. M., Larsson, N.-G. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab. 13: 527-539, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 8/30/2013. 3. Spahr, H., Habermann, B., Gustafsson, C. M., Larsson, N.-G., Hallberg, B. M. Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. Proc. Nat. Acad. Sci. 109: 15253-15258, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.