Anti-NUDT5 Antibody Picoband®

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene. This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors.

Boster Bio Anti-NUDT5 Antibody Picoband® catalog # A07530. Tested in ELISA, IP, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Formin-1; Limb deformity protein homolog; FMN1; FMN, LD

NUDT5

11164

Q9UKK9

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NUDT5 recombinant protein (Position: M1-F219) .

Expressed ubiquitously.

ELISA, IP, IF IHC, ICC, WB, Flow Cytometry

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .

1. Gasmi, L., Cartwright, J. L., McLennan, A. G. Cloning, expression and characterization of YSA1H, a human adenosine 5-prime-diphosphosugar pyrophosphatase possessing a MutT motif. Biochem. J. 344: 331-337, 1999. 2. McLennan, A. G. The MutT family of nucleotide phosphohydrolases in man and human pathogens. Int. J. Molec. Med. 4: 79-89, 1999. 3. Wright, R. H. G., Lioutas, A., Le Dily, F., Soronellas, D., Pohl, A., Bonet, J., Nacht, A. S., Samino, S., Font-Mateu, J., Vicent, G. P., Wierer, M., Trabado, M. A., Schelhorn, C., Carolis, C., Macias, M. J., Yanes, O., Oliva, B., Beato, M. ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling. Science 352: 1221-1225, 2016.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A07530

24,328 MW

35 kDa

6

Formin-1

Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity) . .

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.