Anti-NUDT6 Antibody Picoband® fluoro550 Vervoeging

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene. This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Histone-lysine N-methyltransferase SETDB2; Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2; SETDB2; C13orf4; CLLD8; KMT1F

NUDT6

11162

P53370

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human NUDT6 recombinant protein (Position: D45-K303) .

Highly expressed in reproductive organs, such as testis, ovary and prostate.

Flow Cytometry

Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) . H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

1. Asa, S. L., Ramyar, L., Murphy, P. R., Li, A. W., Ezzat, S. The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production. Molec. Endocr. 15: 589-599, 2001. 2. Gagnon, M. L., Moy, G. K., Klagsbrun, M. Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells. J. Cell. Biochem. 72: 492-506, 1999. 3. Murphy, P. R., Knee, R. S. Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene. Molec. Endocr. 8: 852-859, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

SET domain bifurcated histone lysine methyltransferase 2

Nucleus. Chromosome.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.