Anti-ODF2 Antibody Picoband® 0,00647 Vervoeging

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers.

ODF2; Outer dense fiber protein 2; Cenexin; Outer dense fiber of sperm tails protein 2

ODF2

4957

Q5BJF6

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human ODF2 recombinant protein (Position: R11-A829) . Human ODF2 shares 97.2% amino acid (aa) sequence identity with mouse ODF2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Brohmann, H., Pinnecke, S., Hoyer-Fender, S. Identification and characterization of new cDNAs encoding outer dense fiber proteins of rat sperm. J. Biol. Chem. 272: 10327-10332, 1997. 2. Kunimoto, K., Yamazaki, Y., Nishida, T., Shinohrara, K., Ishikawa, H., Hasegawa, T., Okanoue, T., Harnada, H., Noda, T., Tamura, A., Tsukita, S., Tsukita, S. Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell 148: 189-200, 2012. 3. Scott, A. F. Personal Communication. Baltimore, Md. 9/10/1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

95 kDa

6

Outer dense fiber of sperm tails 2

Outer dense fiber protein 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.