Anti-OGDHL Antilichaam Picoband® fluoro488 Vervoeging

The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells.

RNA-binding protein Nova-2; Astrocytic NOVA1-like RNA-binding protein; Neuro-oncological ventral antigen 2; NOVA2; ANOVA; NOVA3

OGDHL

55753

Q9ULD0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human OGDHL recombinant protein (Position: M1-F1010) .

Brain. Expression restricted to astrocytes.

Flow Cytometry

Channels, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

May regulate RNA splicing or metabolism in a specific subset of developing neurons. Binds single strand RNA.

1. Bunik, V. I., Degtyarev, D. Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. Proteins 71: 874-890, 2008. 2. Nagase, T., Ishikawa, K., Kikuno, R., Hirosawa, M., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 337-345, 1999. 3. Sen, T., Sen, N., Noordhuis, M. G., Ravi, R., Wu, T.-C., Ha, P. K., Sidransky, D., Hoque, M. O. OGDHL is a modifier of AKT-dependent signaling and NF-kappaB function. PLoS One 7: e48770, 2012. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

29370 MW

6

NOVA alternative splicing regulator 2

Nucleus.

Aquaporin-6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.