Anti-OGFOD2 Antibody Picoband® fluoro488 Vervoeging

Predicted to enable several functions, including L-ascorbic acid binding activity; dioxygenase activity; and iron ion binding activity.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

OGFOD2

79676

Q6N063

Human

No cross-reactivity with other proteins.

E.coli-derived human OGFOD2 recombinant protein (Position: R8-R293) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Ripke, S. , O'Dushlaine, C. , Chambert, K. , Moran, J. L. , & Kahler, A. K. . (2013) . Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics. 2. Abraham, C. G. , Ludwig, M. P. , Andrysik, Z. , Galbraith, M. D. , Sullivan, K. D. , & Correspondence, J. M. E. . Δnp63α suppresses tgfb2 expression and rhoa activity to drive cell proliferation in squamous cell carcinomas. Cell reports, 24 (12), 3224-3236. 3. Ripke, S. , Neale, B. M. , Corvin, A. , Walters, J. , Farh, K. H. , & Al, E. . Biological insights from 108 schizophrenia-associated genetic loci. Nature.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.