Anti-OPRM1 Antilichaam Picoband® fluoro594 Vervoeging

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR) . The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.

Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; MMP-1; 22 kDa interstitial collagenase; 27 kDa interstitial collagenase; MMP1; CLG

OPRM1

4988

P35372

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human OPRM1 recombinant protein (Position: N33-H321) .

Flow Cytometry

Chromosome Structure, DNA/RNA, DNA Damage & Repair, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

1. Agirregoitia, E., Valdivia, A., Carracedo, A., Casis, L., Gil, J., Subiran, N., Ochoa, C., Irazusta, J. Expression and localization of delta-, kappa-, and mu-opioid receptors in human spermatozoa and implications for sperm motility. J. Clin. Endocr. Metab. 91: 4969-4975, 2006. 2. Arias, A., Feinn, R., Kranzler, H. R. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis. Drug Alcohol Depend. 83: 262-268, 2006. 3. Bart, G., Heilig, M., LaForge, K. S., Pollak, L., Leal, S. M., Ott, J., Kreek, M. J. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Molec. Psychiat. 9: 547-549, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Matrix metallopeptidase 1

Extracellular matrix.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.