Anti-OPTC Antibody Picoband® 31.0550 Vervoeging

Opticin is a protein that in humans is encoded by the OPTC gene. Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1) .

One cut domain family member 2; Hepatocyte nuclear factor 6-beta; HNF-6-beta; One cut homeobox 2; Transcription factor ONECUT-2; OC-2; ONECUT2; HNF6B

OPTC

26254

Q9UBM4

Human, Monkey

No cross-reactivity with other proteins.

E.coli-derived human OPTC recombinant protein (Position: E32-Q250) .

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Flow Cytometry

Epigenetics and Nuclear Signaling, Transcription, Transcription Factors

Immunogen affinity purified.

Liquid

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

1. Friedman, J. S., Faucher, M., Hiscott, P., Biron, V. L., Malenfant, M., Turcotte, P., Raymond, V., Walter, M. A. Protein localization in the human eye and genetic screen of opticin. Hum. Molec. Genet. 11: 1333-1342, 2002. 2. Reardon, A. J., Le Goff, M., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J., Bishop, P. N. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J. Biol. Chem. 275: 2123-2129, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

One cut homeobox 2

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.