Anti-ORC1 Monoklonale Antilichaam (Kloon: 7F6/1)

The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throμghout the cell cycle; however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throμghout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex sμggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.

HSORC1; MmORC1; Origin Recognition Complex 1 (ORC1) ; Origin recognition complex subunit 1 (yeast homolog) like (ORC1L) ; Origin recognition complex subunit 1 like (S. cerevisia; Origin recognition complex subunit 1 like; PARC1; Replication control protein 1

ORC1L

4998

Q13415

Human

Recombinant full-length human ORC1 protein

7F6/1

ELISA

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

ELISA (For coating, order antibody without BSA)

Mouse IgG1, kappa