Anti-OSCAR Antibody Picoband® Biotin Conjugated

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

OSCAR; Osteoclast-associated immunoglobulin-like receptor; Osteoclast-associated receptor; hOSCAR; Polymeric immunoglobulin receptor 3; PIgR-3; PIgR3; Poly-Ig receptor 3

OSCAR

126014

Q8IYS5

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human OSCAR recombinant protein (Position: D19-V282) . Human OSCAR shares 77.3% amino acid (aa) sequence identity with mouse OSCAR.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Barrow, A. D., Palarasah, Y., Bugatti, M., Holehouse, A. S., Byers, D. E., Holtzman, M. J., Vermi, W., Skjodt, K., Crouch, E., Colonna, M. OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes. J. Immun. 194: 3317-3326, 2015. 2. Kim, K., Kim, J. H., Lee, J., Jin, H.-M., Lee, S.-H., Fisher, D. E., Kook, H., Kim, K. K., Choi, Y., Kim, N. Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. J. Biol. Chem. 280: 35209-35216, 2005. 3. Kim, N., Takami, M., Rho, J., Josien, R., Choi, Y. A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J. Exp. Med. 195: 201-209, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

30 kDa

Oxysterol binding protein like 5

Osteoclast-associated immunoglobulin-like receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.