Anti-OTUD6B Antibody Picoband® 0,00647 Vervoeging

OTU domain containing 6B is a protein that in humans is encoded by the OTUD6B gene. This gene encodes a member of the ovarian tumor domain (OTU) -containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells.

OTUD6B; DUBA5; CGI-77; Deubiquitinase OTUD6B; EC 3.4.19.12; DUBA-5; OTU domain-containing protein 6B

OTUD6B

51633

Q8N6M0

Human

No cross-reactivity with other proteins

E.coli-derived human OTUD6B recombinant protein (Position: E66-S293) . Human OTUD6B shares 87.8% amino acid (aa) sequence identity with mouse OTUD6B.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Kayagaki, N., Phung, Q., Chan, S., Chaudhari, R., Quan, C., O'Rourke, K. M., Eby, M., Pietras, E., Cheng, G., Bazan, J. F., Zhang, Z., Arnott, D., Dixit, V. M. DUBA: a deubiquitinase that regulates type I interferon production. Science 318: 1628-1632, 2007. 2. Santiago-Sim, T., Burrage, L. C., Ebstein, F., Tokita, M. J., Miller, M., Bi, W., Braxton, A. A., Rosenfeld, J. A., Shahrour, M., Lehmann, A., Cogne, B., Kury, S., and 33 others. Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features. Am. J. Hum. Genet. 100: 676-688, 2017. 3. Sobol, A., Askonas, C., Alani, S., Weber, M. J., Ananthanarayanan, V., Osipo, C., Bocchetta, M. Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation. Molec. Cancer Res. 15: 117-127, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

34 kDa

6

OTU deubiquitinase 6B

Deubiquitinase OTUD6B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.