Anti-P-Glycoprotein (MDR) ABCB1 Antilichaam (Monoclonal, F4)

P-Glycoprotein, , also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro. MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.

Boster Bio Anti-P-GlycoProtein (MDR) ABCB1 Antibody (Monoclonal, F4) catalog # MA1060. Tested in IHC, ICC, WB applications. This antibody reacts with Human.

Multidrug resistance protein 1A;3.6.3.44; ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 3; P-glycoprotein 3; Abcb1a; Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3

Abcb1a

Human (5243), Mouse (18671), Rat (170913)

P08183

Human

No cross-reactivity with other proteins

Mixture of human and hamster drug-resistant whole cells and crude plasma membranes.

Clone: F4

ABCB1: Expressed in liver, kidney, small intestineand brain.

IHC, ICC, WB

ATPases, Cancer, Lipid Metabolism, Metabolism, Nuclear Import/Export, Plasma Membrane, Protein Trafficking, Signal Transduction

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. .

1. Callen, D. F.; Baker, E.; Simmers, R. N.; Seshadri, R.; Roninson, I. B. : Localization of the human multiple drug resistance gene, MDR1, to 7q21.1. Hum. Genet. 77: 142-144, 1987. 2. de Lannoy, I. A. M.; Silverman, M. : The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Biochem. Biophys. Res. Commun. 189: 551-557, 1992.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1060

140647 MW

200 kDa

No cross reactivity with other proteins.

DNA helicase

Cell membrane; Multi-pass membrane protein.

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

DNA replication licensing factor MCM7

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.