Anti-P Glycoproteïne/ABCB1 Antibody Picoband® 31.0647 Vervoeging

P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1

ABCB1

5243

P08183

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence in the middle region of human P Glycoprotein/ABCB1, which shares 78.9% amino acid (aa) sequence identity with mouse ABCB1.

Expressed in liver, kidney, small intestine and brain.

Flow Cytometry

Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

1. Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G (March 2009) . 2. Ueda K, Clark DP, Chen CJ, Roninson IB, Gottesman MM, Pastan I (January 1987) . The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J. Biol. Chem.262 (2) : 505–8.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

25283 MW

6

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Cell membrane; Multi-pass membrane protein.

Vascular endothelial growth factor A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.