Anti-P Glycoproteïne/ABCB1 Antibody Picoband® 31.0647 Vervoeging

P-GP, also called ABCB1 or PGY1, is a glycoprotein that in humans is encoded by the ABCB1 gene. It is mapped to 7q21.12. P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily. It is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent drug efflux pump with broad substrate specificity. P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1

ABCB1

5243

P08183

Human

No cross-reactivity with other proteins.

E.coli-derived human P Glycoprotein/ABCB1 recombinant protein (Position: M1-E690) .

Expressed in liver, kidney, small intestine and brain.

Flow Cytometry

Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

1. Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G (March 2009) . 2. Ueda K, Clark DP, Chen CJ, Roninson IB, Gottesman MM, Pastan I (January 1987) . The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J. Biol. Chem.262 (2) : 505–8.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

25283 MW

6

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Cell membrane; Multi-pass membrane protein.

Vascular endothelial growth factor A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.