Anti-P2X6/P2RX6 Antibody Picoband® 310647 Vervoeging

Purinergic receptor P2X-Like 1, also known as P2X6, is a protein that in humans is encoded by the P2RX6 gene. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. This gene belongs to the family of P2X receptors. P2RXL1 gene was mapped to chromosome 22q11 by fluorescence in situ hybridization. This gene is a receptor for ATP that acts as a ligand-gated ion channel. It can mediate rapid and selective permeability to cations.

P2X purinoceptor 6; P2X6; ATP receptor; P2XM; Purinergic receptor; Purinergic receptor P2X-like 1; P2RX6; P2RXL1, P2X6

P2RX6

9127

O15547

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human P2X6.

Expressed predominantly in skeletal muscle.

Flow Cytometry

Cancer, Cardiovascular, Ligand-Gated Ion Channels, Metabolism, Neuroscience, Neurotransmission, Plasma Membrane, Receptors / Channels, Signal Transduction, Vasculature

Immunogen affinity purified.

Liquid

Receptor for ATP that acts as a ligand-gated ion channel. .

1. Collo, G., North, R. A., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A., Buell, G. Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J. Neurosci. 16: 2495-2507, 1996. 2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999) . The DNA sequence of human chromosome 22.Nature 402 (6761) : 489–95. 3. Urano, T., Nishimori, H., Han, H., Furuhata, T., Kimura, Y., Nakamura, Y., Tokino, T.Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res. 57: 3281-3287, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

48829 MW

No cross reactivity with other proteins.

6

P2X purinoceptor 6

Membrane; Multi-pass membrane protein.

Belongs to the P2X receptor family.

P2X purinoceptor 6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.