Anti-p53 Monoklonale Antilichaam (Kloon: BP53-12)

The p53 tumor antigen is found in increased amounts in a wide variety of transformed cells. The protein is also detectable in many actively proliferating, nontransformed cells, but it is undetectable or present at low levels in resting cells. This protein induces cell cycle arrest or apoptosis in response to sublethal or severe DNA damage, respectively, by differential transcription of target genes and through transcription-independent apoptotic functions. The p53 protein contains 393 amino acids. Human p53 tumour antigen is Locatedto band 17p13. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.

Cellular tumor antigen p53; Tumor suppressor p53; Tp53; P53

Tp53

24842

P10361

Human

Recombinant human wild-type p53 protein.

Cellular tumor antigen p53

BP53-12

WB, IHC-P, IHC-F, ICC

Ascites

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. Reconstitute : Add 1ml of PBS buffer will yield a concentration of 100ug/mL.

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Western blot : 0.5-1μg/ml; Immunohistochemistry (Paraffin-embedded Section) : 0.5-2μg/ml; Immunohistochemistry (Frozen Section) : 0.5-2μg/ml; Immunocytochemistry : 1μg/ml

Mouse IgG2a