Anti-PACSIN2 Antibody Picoband® 0,00647 Vervoeging

Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the PACSIN2 gene. This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants.

Transforming acidic coiled-coil-containing protein 1; Gastric cancer antigen Ga55; Taxin-1; TACC1; KIAA1103

PACSIN2

11252

Q9UNF0

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PACSIN2 recombinant protein (Position: M84-D397) .

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .

Flow Cytometry

Cell Biology, Cell Cycle, Cell Differentiation, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.

1. de Kreuk, B.-J., Anthony, E. C., Geerts, D., Hordijk, P. L. The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. J. Biol. Chem. 287: 43438-43453, 2012. 2. Plomann, M., Lange, R., Vopper, G., Cremer, H., Heinlein, U. A. O., Scheff, S., Baldwin, S. A., Leitges, M., Cramer, M., Paulsson, M., Barthels, D. PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells. Europ. J. Biochem. 256: 201-211, 1998. 3. Ritter, B., Modregger, J., Paulsson, M., Plomann, M. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. FEBS Lett. 454: 356-362, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

87794 MW

6

Transforming acidic coiled-coil-containing protein 1

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .

Transforming acidic coiled-coil-containing protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.