Anti-PAK5 Antilichaam

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK5 was initially identified as a kinase expressed primarily in brain that while possessing a kinase domain and GTPase binding domain similar to PAK4 and PAK6, is completely different from both. Expression of PAK5 in neural based cell lines resulted in neurite outgrowth suggesting that PAK5 may be involved in regulating the cytoskeletal changes necessary for promoting neurite outgrowth. Other experiments suggest that unlike the other PAKs, PAK5 may inhibit apoptosis by phosphorylating the Bcl-2 family member Bad.

Boster Bio Anti-PAK5 Antibody (Catalog # A31791) . Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.

PAK5, KIAA1264, PAK5, p21-activated kinase 5, PAK-5

PAK7

Q9P286

Human

PAK5 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK5. The immunogen is located within amino acids 240 - 290 of PAK5.

Predominantly expressed in brain.

ELISA, WB, ICC, IF

Signal Transduction, Homeostasis, Neuroscience

PAK5 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A31791

80745 MW

P21 protein (Cdc42/Rac) -activated kinase 7

Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

Mouse, Rat

P21 protein (Cdc42/Rac) -activated kinase 7

IgG

PAK5 Antibody is supplied in PBS containing 0.02% sodium azide.