Anti-PAR-3/PARD3 Antibody Picoband® fluoro647 Vervoeging

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene. This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.

C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1

PARD3

56288

Q8TEW0

Human

No cross-reactivity with other proteins.

E.coli-derived human PAR-3/PARD3 recombinant protein (Position: M1-Q1346) .

Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

1. Chan, J. R., Jolicoeur, C., Yamauchi, J., Elliott, J., Fawcett, J. P., Ng, B. K., Cayouette, M. The polarity protein Par-3 ly interacts with p75 (NTR) to regulate myelination. Science 314: 832-836, 2006. 2. Chen, X., An, Y., Gao, Y., Guo, L., Rui, L., Xie, H., Sun, M., Lam Hung, S., Sheng, X., Zou, J., Bao, Y., Guan, H., Niu, B., Li, Z., Finnell, R. H., Gusella, J. F., Wu, B.-L., Zhang, T. Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation. Hum. Mutat. 38: 378-389, 2017. 3. Coureuil, M., Mikaty, G., Miller, F., Lecuyer, H., Bernard, C., Bourdoulous, S., Dumenil, G., Mege, R.-M., Weksler, B. B., Romero, I. A., Couraud, P.-O., Nassif, X. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science 325: 83-87, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

40895 MW

6

C-C chemokine receptor type 1

Cell membrane; Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.