Anti-PATL2 Antibody Picoband® fluoro488 Vervoeging

Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Predicted to act upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in cytoplasm.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

PATL2

197135

C9JE40

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PATL2 recombinant protein (Position: Q123-Q411) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Chen, B., Zhang, Z., Sun, X., Kuang, Y., Mao, X., Wang, X., Yan, Z., Li, B., Xu, Y., Yu, M., Fu, J., Mu, J., Zhou, Z., Li, Q., Jin, L., He, L., Sang, Q., Wang, L. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am. J. Hum. Genet. 101: 609-615, 2017. 2. Maddirevula, S., Coskun, S., Alhassan, S., Elnour, A., Alsaif, H. S., Ibrahim, N., Abdulwahab, F., Arold, S. T., Alkuraya, F. S. Female infertility caused by mutations in the oocyte-specific translational repressor PATL2. Am. J. Hum. Genet. 101: 603-608, 2017. 3. Scheller, N., Resa-Infante, P., de la Luna, S., Galao, R. P., Albrecht, M., Kaestner, L., Lipp, P., Lengauer, T., Meyerhans, A., Diez, J. Identification of PatL1, a human homolog to yeast P body component Pat1. Biochim. Biophys. Acta 1773: 1786-1792, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.