Anti-Paxilline-antilichaam

Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells. Thus, phosphorylation paxillin at serine 178 may be important during cell migration

Our Paxillin primary antibody from PhosphoSolutions is mouse monoclonal. It detects chicken, human, mouse, and rat Paxillin and is protein a purified. It is great for use in ELISA, WB, ICC, IP.

Our Paxillin primary antibody from PhosphoSolutions is mouse monoclonal. It detects chicken, human, mouse, and rat Paxillin and is Protein A purified. It is great for use in WB, ICC, IP.

PXN

P49023

Chicken, Human, Mouse, and Rat

Clone (M107) was generated from full-length recombinant human paxillin.

Paxillin

M107

Unconjugated

ELISA, WB, ICC, IP

Cell Adhesion Molecules, Extracellular Matrix Proteins, Oncoproteins

Protein A Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

GOmAb

68

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein A purified culture supernatant.

1:1000

1:100

This antibody detects a 68kDa* protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells. Similar results were seen in various cells and tissues from rat, mouse, and chicken origin.

1:100

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_2174719