Anti-PC4/SUB1 Antibody Picoband® (monoclonal, 2D13E3) 3100550 Vervoeging

Activated RNA polymerase II transcriptional coactivator p15, also known as positive cofactor 4 (PC4) or SUB1 homolog, is a protein that in humans is encoded by the SUB1 gene. This gene is mapped to 5p13.3. The transcriptional cofactor PC4 is an ancient single-strand DNA (ssDNA) -binding protein that has a homologue in bacteriophage T5 where it is likely the elusive replicative ssDNA-binding protein. The recombinant PC4 is shown to function identically to the native protein through its interaction with TAFs.

Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein; ACTN3

SUB1

10923

P53999

Human

No cross-reactivity with other proteins.

E.coli-derived human PC4/SUB1 recombinant protein (Position: N62-L127) .

Clone: 2D13E3

Expressed only in a subset of type 2 skeletal muscle fibers.

Flow Cytometry

Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Immunogen affinity purified.

Liquid

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

1. Entrez Gene SUB1: SUB1 homolog (S. cerevisiae) . 2. Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (August 1994) . A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators. Cell 78 (3) : 525–34. 3. Ge H, Roeder RG (August 1994) . Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Cell 78 (3) : 513–23.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Actinin alpha 3 (gene/pseudogene)

Mouse IgG2b

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.