Anti-PD-1 Monoklonale antilichamen (Kloon:IHC001)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T-cell regulators, expressed as a co-receptor on the surface of activated T-cells, B-cells, and macrophages. New studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to anti-tumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific marker for angioimmunoblastic T-cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non€“small-cell lung cancer, melanoma, and renal-cell cancer.
PDCD1||PD1
PDCD1
5133
Q15116
• Mouse
Human
Recombinant human His-PD1
• Monoclonal
IHC001
IHC
Protein A/G Chromatography
Purified
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and
Store at 2°C - 8°C. Do not freeze.
Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.
Mouse IgG2b
Beschrijving
Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T-cell regulators, expressed as a co-receptor on the surface of activated T-cells, B-cells, a
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