Anti-PD-L1 (extracellulair gebied) M051 Antilichaam

Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The B7 family members have conserved regions that include extracellular IgV and IgC domains, and a short cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas. PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, which promotes tumor survival. The blockage of the PD1/PD-L1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy. Several therapies that target PD1/PD-L1 pathways are currently in use or in clinical trials

Our PD-L1 (Extracellular region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human PD-L1 (Extracellular region) and is protein g purified. It is great for use in ELISA, WB, ICC, IP.

Our PD-L1 (Extracellular region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human PD-L1 (Extracellular region) and is Protein G purified. It is great for use in WB, ICC, IP.

Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1, CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

CD274

Q9NZQ7

Human

Clone (M051) was generated from a recombinant protein that included the extracellular region of human PD-L1 protein.

PD-L1 (Extracellular region)

M051

Unconjugated

ELISA, WB, ICC, IP

Apoptosis, Immunology, Oncoproteins

Protein G Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

45-55

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein G purified culture supernatant.

1:1000

1:200

Clone M051 mouse monoclonal antibody detects a 45-55 kDa* protein on SDS-PAGE "Native" or denatured immunoblots of human recombinant PD-L1 extracellular region, and human lung tissue. The antibody works for western blot, immunoprecipitation, immunocytochemistry, and ELISA capture.

1:200

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068483