Anti-PDE4B Antibody Picoband® FITC-vervoeging

This gene is a member of the type IV, cyclic AMP (cAMP) -specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.

PDE4B; DPDE4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; EC 3.1.4.53; DPDE4; PDE32

PDE4B

5142

Q07343

Human, Mouse

No cross-reactivity with other proteins

E.coli-derived human PDE4B recombinant protein (Position: M1-T736) . Human PDE4B shares 96.6% amino acid (aa) sequence identity with rat PDE4B.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M., Ferguson, K. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Molec. Cell. Biol. 13: 6558-6571, 1993. 2. Huston, E., Lumb, S., Russell, A., Catterall, C., Ross, A. H., Steele, M. R., Bolger, G. B., Perry, M. J., Owens, R. J., Houslay, M. D. Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Biochem. J. 328: 549-558, 1997. 3. Livi, G. P., Kmetz, P., McHale, M. M., Cieslinski, L. B., Sathe, G. M., Taylor, D. P., Davis, R. L., Torphy, T. J., Balcarek, J. M. Cloning and expression of cDNA for a human low-K (m), rolipram-sensitive cyclic AMP phosphodiesterase. Molec. Cell. Biol. 10: 2678-2686, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

83 kDa

6

Phosphodiesterase 4B

3',5'-cyclic-AMP phosphodiesterase 4B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.