Anti-PDLIM7 Antibody Picoband® fluoro488 Vervoeging

PDZ and LIM domain protein 7 is a protein that in humans is encoded by the PDLIM7 gene. The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants.

Long-chain-fatty-acid--CoA ligase 4; Long-chain acyl-CoA synthetase 4; LACS 4; ACSL4; ACS4, FACL4, LACS4

PDLIM7

9260

Q9NR12

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PDLIM7 recombinant protein (Position: N275-V457) .

Expressed in the prostate gland and prostate cancers.

Flow Cytometry

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Immunogen affinity purified.

Liquid

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:24269233, PubMed:22633490, PubMed:21242590) . Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590) . Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity) . Modulates prostaglandin E2 secretion (PubMed:21242590) .

1. Bach, I. The LIM domain: regulation by association. Mech. Dev. 91: 5-17, 2000. 2. Durick, K., Gill, G. N., Taylor, S. S. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2. Molec. Cell. Biol. 18: 2298-2308, 1998. 3. Guy, P. M., Kenny, D. A., Gill, G. N. The PDZ domain of the LIM protein enigma binds to beta-tropomyosin. Molec. Biol. Cell 10: 1973-1984, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Acyl-CoA synthetase long chain family member 4

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.