Anti-Peroxiredoxin 2/PRDX2 Antibody Picoband®

PRDX2 (peroxiredoxin 2) also known as NKEFB, PRP, PRX2, PRXII or TPX1, is a  protein  that in humans is encoded by the  PRDX2  gene. This gene encodes a member of the peroxiredoxin family of antioxidant  enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides.  The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8 (+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The  Prdx2  -/- mice were healthy in appearance and fertile. Choi et al. (2005)   demonstrated that  PRDX2  is a negative regulator of PDGF signaling. Prx II deficiency results in increased production of peroxide, enhanced activation of PDGF receptor and phospholipase C-gamma-1, and subsequently increased cell proliferation and migration in response to PDGF. PRX2 accounted for about half of the thioredoxin activity in parasite extracts, and PRX2 expression was increased in the presence of chloroquine, regardless of P. falciparum strain susceptibility to the drug.&nbsp

Boster Bio Anti-Peroxiredoxin 2/PRDX2 Antibody catalog # PA1834. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Peroxiredoxin-2;1.11.1.15; Natural killer cell-enhancing factor B; NKEF-B; PRP; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; PRDX2; NKEFB, TDPX1

PRDX2

7001

P32119

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2, identical to the related mouse and rat sequences.

WB

Alzheimer's Disease, Cancer, Cancer Metabolism, Cell Biology, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Oxidative Stress, Pathways and Processes, Redox Metabolism

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H (2) O (2) .

1. Choi, M. H., Lee, I. K., Kim, G. W., Kim, B. U., Han, Y.-H., Yu, D.-Y., Park, H. S., Kim, K. Y., Lee, J. S., Choi, C., Bae, Y. S., Lee, B. I., Rhee, S. G., Kang, S. W. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature 435: 347-353, 2005. 2. Lee, T.-H., Kim, S.-U., Yu, S.-L., Kim, S. H., Park, D. S., Moon, H.-B., Dho, S. H., Kwon, K.-S., Kwon, H. J., Han, Y.-H., Jeong, S., Kang, S. W., Shin, H.-S., Lee, K.-K., Rhee, S. G., Yu, D.-Y. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 101: 5033-5038, 2003. 3. Pahl, P., Berger, R., Hart, I., Chae, H. Z., Rhee, S. G., Patterson, D. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. Genomics 26: 602-606, 1995.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PA1834

21892 MW

48-52 kDa

No cross reactivity with other proteins.

Peroxiredoxin-2

Cytoplasm.

Belongs to the AhpC/TSA family.

Peroxiredoxin-2

Rabbit IgG

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.