Anti-PHF24 Antilichaam Picoband® fluoro594 Vervoeging

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF24 (PHD finger protein 24), also known as KIAA1045, is a 400 amino acid protein containing one PHD-type zinc finger motif, suggesting involvement in transcriptional regulation events. Conserved in chimpanzee, Rhesus monkey, canine, bovine, mouse, rat, chicken, zebrafish and frog, the gene encoding PHF24 is located on human chromosome 9. Chromosome 9 houses over 900 genes and comprises nearly 4% of the human genome. Considered to play a role in gender determination, deletion of the distal portion of chromosome 9p can lead to development of male to female sex reversal, the phenotype of a female with a male XY genotype.

PHF24

23349

Q9UPV7

Human, Rat

E.coli-derived human PHF24 recombinant protein (Position: D113-K397) . Human PHF24 shares 89.5% amino acid (aa) sequence identity with mouse PHF24.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Gross, M. B. Personal Communication. Baltimore, Md. 6/23/2022. 2. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999. 3. Miyamoto, K., Yamashita, A., Saito, K. Solution structure of the PHD finger from the human KIAA1045 protein. Protein Sci. 27: 987-992, 2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.