Anti-Phospho-IRF3 (S386) Konijn Monoklonale Antilichaam

Boster Bio Anti-Phospho-IRF3 (S386) Rabbit Monoclonal Antibody catalog # P00165. Tested in WB, ICC/IF applications. This antibody reacts with Human.

S386

Interferon regulatory factor 3; IRF-3; IRF3

IRF3

3661

Q14653

Human

A synthesized peptide derived from human Phospho-IRF3 (S386)

Clone: IGO-9

Expressed constitutively in a variety of tissues.

WB, ICC, IF

Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interferons, TLR Signaling, Transcription

Affinity-chromatography

0.5mg/ml

Liquid

Key transcriptional regulator of type I interferon (IFN) -dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=P00165

47219 MW

120 kDa

Interferon regulatory factor 3

Cytoplasm . Nucleus . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.