Anti-Phospho-MDM2 (S166) Konijn Monoklonale Antilichaam

Boster Bio Anti-Phospho-MDM2 (S166) Rabbit Monoclonal Antibody catalog # P00054-2. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

S166

Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110; RB1

MDM2

4193

Q00987

Human, Mouse, Rat

A synthesized peptide derived from human Phospho-MDM2 (S166)

Clone: 29M35

Expressed in the retina.

WB, IHC

Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Epigenetics and Nuclear Signaling, Nucleus, Oncoproteins/Suppressors, Subcellular Markers, Tags & Cell Markers, Transcription, Tumor Suppressors

Affinity-chromatography

0.5mg/ml

Liquid

Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. ly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity) . In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=P00054-2

106159 MW

90-100 kDa

Retinoblastoma-associated protein

Nucleus .

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.