Anti-Phospho-PAK1/2/3 (S144+S141+S139) PAK3 Konijn Monoklonale Antilichaam

Boster Bio Anti-Phospho-PAK1/2/3 (S144+S141+S139) PAK3 Rabbit Monoclonal Antibody catalog # P03124. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

S144, S141, S139

Serine/threonine-protein kinase PAK 3;2.7.11.1; Beta-PAK; Oligophrenin-3; p21-activated kinase 3; PAK-3; PAK3; OPHN3

PAK3

5058

Q13153/Q13177/O75914

Human, Mouse, Rat

A synthesized peptide derived from human Phospho-PAK1/2/3 (S144+S141+S139)

Clone: CFF-16

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

WB, IHC, ICC, IF, IP, Flow Cytometry

Apoptosis, Cancer, Cell Biology, G Protein Signaling, Host-Virus Interaction, Interspecies Interaction, Intracellular, Kinases, Microbiology, Neural Signal Transduction, Neurology Process, Neuroscience, Protein Phosphorylation, Ras Family, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, Signaling Pathway, Small G Proteins

Affinity-chromatography

0.5mg/ml

Liquid

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=P03124

62310 MW

40 kDa

Serine/threonine-protein kinase PAK 3

Cytoplasm .

Glutamate receptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.