Anti-Phosphomevalonaat kinase PMVK Antibody Picoband® fluoroc647 Vervoeging

PMVK (phosphomevalonate kinase) is a cytosolic enzyme that catalyzes the conversion of mevalonate-5-phosphate to mevalonate-5-diphosphate. It is mapped to chromosome 1p13-1q22-23 and spans more than 8.4 kb in the human genome. PMVK is a peroxisomal protein which requires the C-terminal peroxisomal targeting signal, Ser-Arg-Leu, for localization to the organelle. It was expressed highly in heart, liver, skeletal muscle, kidney and pancreas and slightly lower in brain, placenta, and lung. And PMKase gene expression is subject to regulation by sterol at the level of transcription. It is a single copy gene covering less than 15 kb in the human genome. The human PMKase amino acid sequence contains a consensus peroxisomal targeting sequence (PTS-1), Ser-Arg-Leu, at the C terminus of the protein.

Phosphomevalonate kinase; PMKase; hPMK;2.7.4.2; PMVK; PMKI

PMVK

10654

Q15126

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human PMVK, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. .

Flow Cytometry

Cancer, Cancer Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

1. Olivier, L. M.; Chambliss, K. L.; Gibson, K. M.; Krisans, S. K. : Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J. Lipid Res. 40: 672-679, 1999. 2. Chambliss, K. L.; Slaughter, C. A.; Schreiner, R.; Hoffmann, G. F.; Gibson, K. M. : Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J. Biol. Chem. 271: 17330-17334, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

21995 MW

No cross reactivity with other proteins.

6

Phosphomevalonate kinase

Peroxisome .

Phosphomevalonate kinase (PMKase/hPMK)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.