Anti-PI2/SERPINB1 Antibody Picoband® fluoro488 Vervoeging

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.

Stromelysin-3; SL-3; ST3;3.4.24.-; Matrix metalloproteinase-11; MMP-11; MMP11; STMY3

SERPINB1

1992

P30740

Human

No cross-reactivity with other proteins

E.coli-derived human PI2/SERPINB1 recombinant protein (Position: A52-R275) .

Specifically expressed in stromal cells of breast carcinomas.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

May play an important role in the progression of epithelial malignancies.

1. Evans, E., Cooley, J., Remold-O'Donnell, E. Characterization and chromosomal localization of ELANH2, the gene encoding human monocyte/neutrophil elastase inhibitor. Genomics 28: 235-240, 1995. 2. Remold-O'Donnell, E., Chin, J., Alberts, M. Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor. Proc. Nat. Acad. Sci. 89: 5635-5639, 1992. 3. Schneider, S. S., Schick, C., Fish, K. E., Miller, E., Pena, J. C., Treter, S. D., Hui, S. M., Silverman, G. A. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc. Nat. Acad. Sci. 92: 3147-3151, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54590 MW

6

Stromelysin-3

Secreted, extracellular space, extracellular matrix .

Stromelysin-3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.