Anti-PITRM1 Antilichaam

Boster Bio Anti-PITRM1 Antibody catalog # A08969. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Presequence protease, mitochondrial

PITRM1

Q5JRX3

Human, Mouse, Rat

Recombinant fusion protein of human PITRM1 (NP_055704.2) .

Widely expressed. Expressed at higher level in muscle and heart compared to brain, pancreas, liver, lung and placenta.

WB, ICC, IF

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469) . Has an ATP-independent activity (PubMed:16849325) . Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155) . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469) . Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155) . Also degrades other unstructured peptides (PubMed:19196155) . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469) . It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469) . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08969

117413 MW

Presequence protease, mitochondrial

Mitochondrion matrix

Presequence protease, mitochondrial

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2