Anti-Plakophilin-1 (PKP1) Monoklonale Antilichaam (Kloon: 10B2)

Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress) . Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.

B6P; Band 6 protein; PKP1; Plakophilin-1 (ectodermal dysplasia/skin fragility syndrome)

PKP1

5317

Q13835

Human, Mouse

N-terminus of human Plakophilin-1 protein

10B2

FACS, IF, WB

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Flow Cytometry (1-2ug/million cells) ; Immunofluorescence (1-2ug/ml) ; Western Blot (1-2ug/ml)

Mouse IgG1, kappa