Anti-PLCD3 Antibody Picoband® 0,00647 Vervoeging

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene. This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3) . Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca (2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2

PLCD3

113026

Q8N3E9

Human

No cross-reactivity with other proteins.

E.coli-derived human PLCD3 recombinant protein (Position: R10-Q702) .

Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.

Flow Cytometry

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Immunogen affinity purified.

Liquid

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

1. Ghosh, S., Pawelczyk, T., Lowenstein, J. M. Phospholipase C isoforms delta-1 and delta-3 from human fibroblasts: high-yield expression in Escherichia coli, simple purification, and properties. Protein Expr. Purif. 9: 262-278, 1997. 2. Kim, H., Suh, P. G., Ryu, S. H., Park, S. H. Assignment of the human PLC-delta-3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 87: 209-210, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

PR/SET domain 5

Nucleus.

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.