Anti-Pleigonadotrofine/PTN Antibody Picoband®

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

Boster Bio Anti-Pleiotrophin/PTN Antibody catalog # PA1414. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Pleiotrophin; PTN; Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1; OSF-1; PTN; HBNF1, NEGF1

PTN

5764

P21246

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin, identical to the related rat and mouse sequences.

Osteoblast and brain.

IHC, WB

Cancer, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Growth and Development, Growth Factors, Immunology, Innate Immunity, Neurology Process, Neuroscience, Signal Transduction, Structures

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. .

1. Entrez Gene: PTN pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) . 2. Vanderwinden JM, Mailleux P, Schiffmann SN, Vanderhaeghen JJ (1992) . Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat. Embryol. 186 (4) : 387–406. 3. Said EA, Courty J, Svab J, Delbé J, Krust B, Hovanessian AG (September 2005) . Pleiotrophin inhibits HIV infection by binding the cell surface-expressed nucleolin. FEBS J. 272 (18) : 4646–59.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PA1414

19 kDa

19 kDa

No cross reactivity with other proteins.

Pleiotrophin

Secreted.

Belongs to the pleiotrophin family.

Pleiotrophin (PTN)

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.