Anti-PLS1 Antibody Picoband® 31.0550 Vervoeging

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.

PLS1

5357

Q14651

Human, Mouse, Rat

E.coli-derived human PLS1 recombinant protein (Position: E14-L581) . Human PLS1 shares 93.8% amino acid (aa) sequence identity with mouse PLS1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Diaz-Horta, O., Bademci, G., Tokgoz-Yilmaz, S., Guo, S., Zafeer, F., Sineni, C. J., Duman, D., Farooq, A., Tekin, M. Novel variant pE269K confirms causative role of PLA1 mutations in autosomal dominant hearing loss. Clin. Genet. 96: 575-578, 2019. 2. Grimm-Gunter, E-M. S., Revenu, C., Ramos, S., Hurbain, I., Smyth, N., Ferrary, E., Louvard, D., Robine, S., Rivero, F. Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Molec. Biol. Cell 20: 2549-2562, 2009. 3. Lin, C.-S., Shen, W., Chen, Z. P., Tu, Y.-H., Matsudaira, P. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Molec. Cell. Biol. 14: 2457-2467, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

70 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.