Anti-PMP70/ABCD3 Antibody Picoband® fluoro647 Vervoeging

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene was assigned to human chromosome 1p21-p22 by in situ hybridization. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.

ATP-binding cassette sub-family D member 3;70 kDa peroxisomal membrane protein; PMP70; ABCD3; PMP70, PXMP1

ABCD3

5825

P28288

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human PMP70, different from the related mouse and rat sequences by one amino acid.

Flow Cytometry

Alzheimer's Disease, Cancer, Lipid Metabolism, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Organelle Proteins, Organelles, Protein Trafficking, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382) . The nucleotide-binding fold acts as an ATP- binding subunit with ATPase activity (PubMed:11248239) . .

1. Gartner J, Moser H, Valle D (June 1993) . Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome.Nat Genet 1 (1) : 16–23. 2. Gartner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D (April 1993) . Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. Genomics 15 (2) : 412–4. 3. Entrez Gene: ABCD3 ATP-binding cassette, sub-family D (ALD), member 3.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

75 kDa

No cross reactivity with other proteins.

6

ATP-binding cassette sub-family D member 3

Peroxisome membrane ; Multi-pass membrane protein .

Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

ATP-binding cassette sub-family D member 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.