Anti-POLA1 Antibody Picoband®

DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene. This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication.

Boster Bio Anti-POLA1 Antibody Picoband® catalog # A04421-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; TNFSF18; AITRL, GITRL, TL6; UNQ149/PRO175

POLA1

5422

P09884

Human

No cross-reactivity with other proteins.

E.coli-derived human POLA1 recombinant protein (Position: E45-D1429) .

Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

WB, ICC, IF, Flow Cytometry, ELISA

Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569) . Promotes leukocyte adhesion to endothelial cells (PubMed:23892569) . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity) .

1. Adler, D. A., Tseng, B. Y., Wang, T. S.-F., Disteche, C. M. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics 9: 642-646, 1991. 2. Hanaoka, F., Tandai, M., Miyazawa, H., Murakami, Y., Hori, T., Yamada, M. Assignment of human DNA polymerase alpha gene (POLA) to the X chromosome. (Abstract) Cytogenet. Cell Genet. 40: 647 only, 1985. 3. Miyazawa, H., Tandai, M., Hanaoka, F., Yamada, M., Hori, T., Shimizu, K., Sekiguchi, M. Identification of a DNA segment containing the human DNA polymerase alpha gene. Biochem. Biophys. Res. Commun. 139: 637-643, 1986.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A04421-1

180 kDa

6

TNF superfamily member 18

Cell membrane

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.