Anti-POLD3 Antibody Picoband® 31.0550 Vervoeging

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene. This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA) . Alternatively spliced transcript variants have been observed for this gene.

POLD3

10714

Q15054

Human, Mouse, Rat

E.coli-derived human POLD3 recombinant protein (Position: D11-K296) . Human POLD3 shares 87.8% amino acid (aa) sequence identity with mouse POLD3.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Dilley, R. L., Verma, P., Cho, N. W., Winters, H. D., Wondisford, A. R., Greenberg, R. A. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature 539: 54-58, 2016. 2. Hughes, P., Tratner, I., Ducoux, M., Piard, K., Baldacci, G. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Nucleic Acids Res. 27: 2108-2114, 1999. 3. Liu, G., Warbrick, E. The p66 and p12 subunits of DNA polymerase delta are modified by ubiquitin and ubiquitin-like proteins. Biochem. Biophys. Res. Commun. 349: 360-366, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.