Anti-POLR1A Antibody Picoband® 31.0647 Vervoeging

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis.

POLR1A; DNA-directed RNA polymerase I subunit RPA1; RNA polymerase I subunit A1; EC 2.7.7.6; A190; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RPA194

POLR1A

25885

O95602

Human

No cross-reactivity with other proteins

E.coli-derived human POLR1A recombinant protein (Position: E607-R1720) . Human POLR1A shares 86.3% and 87.3% amino acid (aa) sequence identity with mouse and rat POLR1A, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. da Rocha, L. A., Pires, L. V. L., Yamamoto, G. L., Magliocco Ceroni, J. R., Honjo, R. S., de Novaes Franca Bisneto, E., Oliveira, L. A. N., Rosenberg, C., Krepischi, A. C. V., Passos-Bueno, M. R., Kim, C. A., Bertola, D. R. Congenital limb deficiency: genetic investigation of 44 individuals presenting mainly longitudinal defects in isolated or syndromic forms. Clin. Genet. 100: 615-623, 2021. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 6/2/2015. 3. Kara, B., Koroglu, C., Peltonen, K., Steinberg, R., Maras Genc, H., Holtta-Vuori, M., Guven, A., Kanerva, K., Kotil, T., Solakoglu, S., Zhou, Y., Olkkonen, V. M., Ikonen, E., Laiho, M., Tolun, A. Severe neurodegenerative disease in brothers with homozygous mutation in POLR1A. Europ. J. Hum. Genet. 25: 315-323, 2017.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

195 kDa

6

RNA polymerase I subunit A

DNA-directed RNA polymerase I subunit RPA1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.