Anti-POLR1D Antilichaam Picoband® fluoro488 Vervoeging

DNA-ed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the POLR1D gene. The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants.

POLR1D

51082

P0DPB6

Human, Mouse, Rat

E.coli-derived human POLR1D recombinant protein (Position: K10-F133) . Human POLR1D shares 90.3% amino acid (aa) sequence identity with mouse POLR1D.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Benedetti, F., Amanzio, M., Rosato, R., Blanchard, C. Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature Med. 17: 1228-1230, 2011. 2. Berghuis, P., Dobszay, M. B., Wang, X., Spano, S., Ledda, F., Sousa, K. M., Schulte, G., Ernfors, P., Mackie, K., Paratcha, G., Hurd, Y. L., Harkany, T. Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proc. Nat. Acad. Sci. 102: 19115-19120, 2005. 3. Berghuis, P., Rajnicek, A. M., Morozov, Y. M., Ross, R. A., Mulder, J., Urban, G. M., Monory, K., Marsicano, G., Matteoli, M., Canty, A., Irving, A. J., Katona, I., Yanagawa, Y., Rakic, P., Lutz, B., Mackie, K., Harkany, T. Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science 316: 1212-1216, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.