Anti-POLR3G-antilichaam

Boster Bio Anti-POLR3G Antibody catalog # A10669. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

DNA-directed RNA polymerase III subunit RPC7; RNA polymerase III subunit C7; DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa subunit; RPC32; POLR3G

POLR3G

O15318

Human, Mouse

The antiserum was produced against synthesized peptide derived from the Internal region of human POLR3G. AA range:151-200

WB, IHC, IF, ELISA

Immunogen affinity purified

1 mg/mL

Liquid

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A10669

25914 MW

DNA-directed RNA polymerase III subunit RPC7

Nucleus .

IgG

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.