Anti-POU6F2 Antibody Picoband® APC-vervoeging

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

POU6F2; RPF1; POU domain, class 6, transcription factor 2; Retina-derived POU domain factor 1; RPF-1

POU6F2

11281

P78424

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human POU6F2 recombinant protein (Position: E24-Q446) . Human POU6F2 shares 89.7% amino acid (aa) sequence identity with mouse POU6F2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Gross, M. B. Personal Communication. Baltimore, Md. 4/5/2019. 2. Perotti, D., De Vecchi, G., Testi, M. A., Lualdi, E., Modena, P., Mondini, P., Ravagnani, F., Collini, P., Di Renzo, F., Spreafico, F., Terenziani, M., Sozzi, G., Fossati-Bellani, F., Radice, P. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14. Hum. Mutat. 24: 400-407, 2004. 3. Perotti, D., Testi, M. A., Mondini, P., Pilotti, S., Green, E. D., Pession, A., Sozzi, G., Pierotti, M. A., Fossati Bellani, F., Radice, P. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours. Genes Chromosomes Cancer 31: 42-47, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

73 kDa

6

POU class 6 homeobox 2

POU domain, class 6, transcription factor 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.