Anti-PPM1N Antibody Picoband® fluoro594 Vervoeging

Predicted to enable metal ion binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytosol and nucleus.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

PPM1N

147699

Q8N819

Human

No cross-reactivity with other proteins.

E.coli-derived human PPM1N recombinant protein (Position: R36-A430) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Zhou, H. , Xu, M. , Huang, Q. , Gates, A. T. , Zhang, X. D. , & Castle, J. C. , et al. (2008) . Genome-scale rnai screen for host factors required for hiv replication. Cell host & microbe, 4 (5), 495-504. 2. Shi, P. , Guo, Y. , Su, Y. , Zhu, M. , & Huang, J. . (2020) . Sumoylation of ddx39a alters binding and export of antiviral transcripts to control innate immunity. The Journal of Immunology, 205 (1), ji2000053. 3. Fasci, D. , Ingen, H. V. , Scheltema, R. A. , & Heck, A. J. R. . (2018) . Histone interaction landscapes visualized by crosslinking mass spectrometry in intact cell nuclei. Molecular & Cellular Proteomics Mcp, 17 (10), mcp.RA118.000924.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.