Anti-PPP1R11 Antibody Picoband®

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene. This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.

Boster Bio Anti-PPP1R11 Antibody Picoband® catalog # A10474-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991

PPP1R11

6992

O60927

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PPP1R11 recombinant protein (Position: M1-H126) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

WB, Flow Cytometry, ELISA

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

1. Amadou, C., Ribouchon, M. T., Mattei, M. G., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Avoustin, P., Pontarotti, P. Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. Genomics 26: 9-20, 1995. 2. el Kahloun, A., Chauvel, B., Mauvieux, V., Dorval, I., Jouanolle, A.-M., Gicquel, I., Le Gall, J.-Y., David, V. Localization of seven new genes around the HLA-A locus. Hum. Molec. Genet. 2: 55-60, 1993. 3. Giffon, T., Lepourcelet, M., Pichon, L., Jezequel, P., Bouric, P., Carn, G., Pontarotti, P., Le Gall, J.-Y., David, V. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. Immunogenetics 44: 331-339, 1996.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A10474-2

41409 MW

25 kDa

6

Ring finger protein 169

Nucleoplasm.

Protein NDRG3

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.