Anti-PPP1R11 Antibody Picoband® fluoro647 Vervoeging

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene. This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6.

E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169; RNF169; KIAA1991

PPP1R11

6992

O60927

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PPP1R11 recombinant protein (Position: M1-H126) .

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Flow Cytometry

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

1. Amadou, C., Ribouchon, M. T., Mattei, M. G., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Avoustin, P., Pontarotti, P. Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes. Genomics 26: 9-20, 1995. 2. el Kahloun, A., Chauvel, B., Mauvieux, V., Dorval, I., Jouanolle, A.-M., Gicquel, I., Le Gall, J.-Y., David, V. Localization of seven new genes around the HLA-A locus. Hum. Molec. Genet. 2: 55-60, 1993. 3. Giffon, T., Lepourcelet, M., Pichon, L., Jezequel, P., Bouric, P., Carn, G., Pontarotti, P., Le Gall, J.-Y., David, V. Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. Immunogenetics 44: 331-339, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

41409 MW

6

Ring finger protein 169

Nucleoplasm.

Protein NDRG3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.