Anti-PPP1R13B Antilichaam Picoband® fluoro488 Vervoeging

Apoptosis-stimulating of p53 protein 1 is a protein that in humans is encoded by the PPP1R13B gene. This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.

Rab3 GTPase-activating protein non-catalytic subunit; RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit; RAB3GAP2; KIAA0839

PPP1R13B

23368

Q96KQ4

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human PPP1R13B recombinant protein (Position: F901-A1090) .

Ubiquitous.

Flow Cytometry

Developmental Biology, G Protein Signaling, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Neurotransmission, Organogenesis, Protein Trafficking, Regulators, Secretory Vesicles, Signal Transduction, Signaling Pathway, Small G Proteins, Vesicle Transport

Immunogen affinity purified.

Liquid

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D) . Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

1. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998. 2. Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., Lu, X. ASPP proteins specifically stimulate the apoptotic function of p53. Molec. Cell 8: 781-794, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67166 MW

6

RAB3 GTPase activating non-catalytic protein subunit 2

Cytoplasm.

Suppressor of tumorigenicity 7 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.