Anti-PPP1R36 Antibody Picoband® fluoro647 Vervoeging

PPP1R36 (protein phosphatase 1, regulatory subunit 36) is a protein-coding gene. GO annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

PPP1R36

145376

Q96LQ0

Human

No cross-reactivity with other proteins.

E.coli-derived human PPP1R36 recombinant protein (Position: R44-D381) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Gross, M. B. Personal Communication. Baltimore, Md. 6/16/2022. 2. Gross, N., Strillacci, M. G., Penagaricano, F., Khatib, H. Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos. Sci. Rep. 9: 20347, 2019. 3. Zhang, Q., Gao, M., Zhang, Y., Song, Y., Cheng, H., Zhou, R. The germline-enriched Ppp1r36 promotes autophagy. Sci. Rep. 6: 24609, 2016.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.